Diagram csf flow pathway. Crump institute for biological imaging. The pathway and extent are currently not known but may involve csf flow along some cranial nerves and be more prominent in the neonate. Csf is produced by the choroid plexus within the lateral and fourth ventricles. Animation of cerebrospinal fluid circulation credit.
It is less clear how csf flows below a csf obstruction as for example when documented by an intralumbar radionuclide csf flow study perhaps spinal dural venous plexus pulsations contribute to cephalad flow. Diagram of the csf circulation. Csf is formed within the ventricles by small delicate tufts of specialized tissue called the choroid plexus. It is a multifaceted marvel able to continuously support the nervous system through the lifespan of the organism.
Cerebrospinal fluid csf is a clear proteinaceous fluid that exists in the surrounding spaces of mammalian central nervous systems cns. Lateral ventricles foramen of monro third ventricle aqueduct of sylvius fourth ventricle foramina of magendie and luschka. Subarachnoid space over brain and spinal cord. Nascent csf is more than a passive ultrafiltrate of plasma.
Csf circulation from sites of secretion to sites of absorption largely depends on the arterial pulse wave. Beginning in the lateral ventricles csf flows through two passageways into the third ventricle. In the average adult human there is roughly 150 ml of csf circulating at any given moment. Chapter 33 production and flow of cerebrospinal fluid.
Additional factors such as respiratory waves the subjects posture jugular venous pressure and physical effort also modulate csf flow dynamics and pressure. Therefore when radioisotope is administered intraventricularly flow is expected to the level of csf obstruction 31 33. Csf has also been seen to drain into lymphatic vessels particularly those surrounding the nose via drainage along the olfactory nerve through the cribriform plate. The ventricular portion amounts to roughly 17 of.
The solid arrows in the drawing below cerebrospinal fluid csf circulatory pathway show the major pathway of csf flow. Csf flows as a consequence of both transmitted choroidal arterial pulsations and due to bulk flow resulting from continuous csf production. Csf flow chart csf flow diagram 4253036343631 pathway of csf flow chart 40 file. December 19th 2018 download now.
Aquaporins and other transporters control the fluid exchange at the glial endothelial and. 1 day and night the choroid plexus churns out fluid into the ventricles. Csf formation is about 04 mlmin per gram of choroid plexus. Normally the pathway of flow is.